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Celebrex May Induce Arrhythmia, Study Finds

Filed January 28th, 2008 amy

ConsumerAffairs.com reported January 25 that Celebrex, a popular arthritis drug that blocks pain by inhibiting an enzyme known as COX-2, has been shown in laboratory studies to induce arrhythmia, or irregular beating of the heart.

University at Buffalo researchers, conducting basic research on potassium channels, found that low concentrations of the drug reduced the heart rate and induced pronounced arrhythmia in fruit flies and the heart cells of rats. The drug inhibited the normal passage of potassium ions into and out of heart cells through pores in the cell membrane known as delayed rectifier potassium channels, according to the study, which appears in the Jan. 18 edition of the Journal of Biological Chemistry.

“The adverse effects of drugs like Celebrex and Vioxx based on their selective inhibition of COX-2 Online casino US currently are a topic of intense discussion in the medical community,” said Satpal Singh, Ph.D., associate professor of pharmacology and toxicology in the UB School of Medicine and Biomedical Sciences and senior author on the study. Vioxx was withdrawn from the market in September 2004.

“We now have shown an important new effect of Celebrex through a totally different pathway, one that is unrelated to the drug’s effect as a pain reducer,” Singh said. “The adverse effect arising from this unexpected mechanism definitely needs to be studied more closely, because the potassium channels inhibited by the drug are present in heart, brain and many other tissues in the human body.

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