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Cisplatin Associated More Blood Clot Injuries Than Other Chemotherapy Treatments

Filed November 16th, 2012 Laurie

The results of a new study published online in the Journal of Clinical Pharmacology show that cisplatin-based chemotherapy treatments are associated with a greater risk of blood clots in advanced solid tumor patients than non-cisplatin treatment regimens.

Cisplatin is a chemotherapy drug that was approved by the U.S. Food and Drug Administration (FDA) in 1978 under the name Platinol, and is used to treat sarcoma, small cell lung cancer, lymphoma, germ cell tumors, ovarian cancer, and other cancers. For this study, researchers looked at 8,216 patient records, which were combined from 38 clinical trials from 1990 through 2010. Researchers found that the rate of venous thromboembolic events (VTEs) in patients receiving cisplatin was 1.92 percent, compared to 0.79 percent in patients receiving other chemotherapy treatments, said the Drug Safety Monitor.

There were a total of 24,148 adverse events listing cisplatin as a suspect drug, with 7,406 of those reports listing cisplatin as the primary suspect. The most commonly reported side effects were dehydration, vomiting, and nausea. Cisplatin was also listed as the primary suspect in 1,158 patient deaths and 4,846 hospitalizations, the Drug Safety Monitor reported.

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