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Evidence of Actos Bladder Cancer Connection Continues to Mount

Filed July 5th, 2012 Laurie

A new analysis of previous studies has provided further proof that sufferers of type 2 diabetes have an increased risk of developing bladder cancer, and taking the diabetes drug Actos may increase that risk even more.

According to the analysis, taking Actos raised the risk of bladder cancer by about one-fifth. The individual risk of developing bladder cancer still remained quite low.

“The evidence suggests that this drug is associated with about a 22 percent increased risk of bladder cancer,” said study senior author Jeffrey A. Johnson, the Canada Research Chair in Diabetes Health Outcomes at the University of Alberta School of Public Health, in Canada.

A study published in BMJ found that taking Actos for two years can double the risk.

It is not yet clear just how Actos raises the risk of bladder cancer, but some animal studies seem to suggest the drug could cause crystals to form that irritate the bladder, which could potentially play a role in the development of bladder cancer.
The risk for bladder cancer is higher in men and in smokers.

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