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PPI drugs linked to higher rate of kidney transplant rejections

Filed November 7th, 2012 Joshua Sophy

Kidney transplant patients who take Proton Pump Inhibitor (PPI) drugs in combination with mycophenolate mofetil (MMF) in the year following their surgeries are more likely to experience organ rejection than patients taking another acid-reducing drug.

According to a report from RenalandNeurologyNews.com, researchers at Einstein Medical Center, Philadelphia, found that among 225 people prescribed a PPI drug in combination with MMF, 20 percent experienced rejection in the first year following the surgery. The risk was just 16.4 percent among patients taking ranitidine simultaneously with MMF. That represents a 50 percent increased risk of organ rejection associated with taking PPI drugs.

The risk of transplant rejection was not seen after a year among people taking PPI drugs to prevent gastroesophageal reflux disease.

This is the first study to examine the impact each acid-suppression drug has on renal transplant patients. To reach the conclusion, researchers in Philadelphia examined the histories of 615 renal transplant cases.

The study represents the latest to show some of the many dangerous side effects associated with taking PPI drugs like Nexium, Propecia, Prevacid, and Protonix. The data from the study was recently presented to the Kidney Week 2012 conference in San Diego, according to the report

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