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Report Highlights Dangers of Statin Use

Filed March 22nd, 2013 edlieber1

High-dose statin use may be linked to an increased risk of acute kidney injury, according to a British Medical Journal (BMJ) published report.

The BMJ report, which ran on Tuesday, studied the relationship between statin potency and kidney injury. Researchers looked at data from more than 2 million patient records filed between 1997 and 2008 that were gathered from provinces in Canada and databases from the United Kingdom and the United States, said. High-statin potency was defined as at least 40 mg of Zocor, at least 20 mg of Lipitor and at least 10 mg of Crestor. The study focused on new statin users who were 40 years and older.

Researchers found that patients who did not have a previous diagnosis of kidney disease and were prescribed a high-dose statin were 34 percent more likely to be admitted to the hospital for acute kidney injury within 120 days of treatment, compared to patients who were treated with a low-dose statin, said. The investigators surmised that patients given high-potency statins showed an increased risk for hospitalization due to acute kidney injury compared to patients given lower-potency statins, said.

Since the increased risk for kidney injury was found to be most serious in users who took statins for two years or longer, researchers recommended that prescribing physicians take the risk into consideration when selecting treatment options for patients.

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