Case Review Form

      * Denotes required field.


      * First Name

      * Last Name

      * Email Address

      * Phone Number

      Cell Phone Number

      Office Phone Number

      Street Address




      Zip Code

      Please provide the best method and times to contact you:

      Date of birth of injured person

      Name of drug:

      Date you started taking the drug (mm-yyyy):

      Date you stopped taking the drug (mm-yyyy):

      Please describe any side effects:

      Other Info:

      No Yes, I agree to the Parker & Waichman LLP disclaimers.Click here to review all.

      Yes, I would like to receive the Parker & Waichman LLP monthly newsletter, InjuryAlert.

      please do not fill out the field below.

Study Links Some Chemotherapy Drugs to Lethal Skin Conditions

Filed October 29th, 2013 Laurie

Certain chemotherapy drugs have been linked to serious and lethal dermatologic side effects, including toxic epidermal necrolysis (TEN) and Stevens-Johnson Syndrome (SJS), according to findings published in the October 8 online issue of the journal Anticancer Drugs. TEN is a more severe form of SJS, though both are potentially fatal conditions that can cause cell death in the skin and mucus membranes, Drug Safety Monitor reported.

For the study, researchers culled data from existing literature and national databases, and analyzed the frequency of TEN and SJS, which are considered uncommon adverse events (AEs). Researchers examined cases reported in published literature as well as reports listed in the U.S. Food and Drug Administration (FDA)’s Adverse Event Reporting System (FAERS). A total of 46 cases of SJS and 37 cases of TEN were identified in patients using chemotherapy drugs, according to Drug Safety Monitor.

Investigators stated that FAERS data demonstrated a significant association between the antineoplastic medications bendamustine (brand name Treanda) and SJS, while TEN was linked to bendamustine (Treanda), busulfan (Myleran), chlorambucil (Leukeran), fludarabine (Fludara, Oforta), lomustine (CeeNU), and procarbazine (Matulane). Antineoplastic medications are used to treat various types of cancers, including leukemias, lymphomas, brain tumors, and Hodgkin’s disease, Drug Safety Monitor reported.

According to Drug Safety Monitor, researchers used FAERS data (from 11/01/1997 to 12/31/2012) that was then aggregated and standardized by the AdverseEvent RxFilter process to identify 51 cases of SJS and 33 cases of TEN. The antineoplastic medications noted above were indicated as the primary suspect. Forty-four patients were hospitalized, and 21 patients died.

Be Sociable, Share!

Comments are closed.

Click Here Now, to Have an Attorney Answer Your
Medicinal Drug Injuries Questions
No Cost - No Obligation!